Exploit.DEPDisableAttempt is Malwarebytes' detection name for attempts to disable Data Execution Protection (DEP)
Exploit.DEPDisableAttempt blocks attempt to disable DEP. DEP is a system-level memory protection feature that is built into the Windows operating system. It monitors processes so they don't execute code in certain areas in the computer’s memory which aren’t intended to have code running in them.
Malwarebytes guards the DEP protection with Exploit.DEPDisableAttempt and displays the warning Exploit attempt to disable DEP blocked
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